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Single AAV Injection Extends Lifespan and Multi-Organ Health in Aged Mice
A single AAV injection carrying the FGF21 gene raised median lifespan by 20% in aged mice and preserved function across five organ systems. The 27-month study, led by Professor Fátima Bosch, treated mice after age-related decline had already begun—a design closer to clinical reality than most longevity research.